Pharmacokinetic and Pharmacodynamic Modeling of MOD-4023, a Long-Acting Human Growth Hormone, in Growth Hormone Deficiency Children

BACKGROUND/AIMS: MOD-4023 is a long-acting human growth hormone (hGH) in clinical trials for the treatment of growth hormone deficiency (GHD). A key goal is maintenance of serum concentrations of insulin-like growth factor (IGF) 1 within normal range throughout GH dosing. The study aimed to develop...

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Detalhes bibliográficos
Publicado no:Horm Res Paediatr
Main Authors: Fisher, Dennis M., Rosenfeld, Ron G., Jaron-Mendelson, Michal, Amitzi, Leanne, Koren, Ronit, Hart, Gili
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637306/
https://ncbi.nlm.nih.gov/pubmed/28399519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000470842
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