Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway

Sirtuin 7 (SIRT7) is a NAD(+)-dependent deacetylase in the sirtuin family. In a previous study, human bone marrow mesenchymal stem cells (hBMSCs) with reduced SIRT7 activity were developed to evaluate the effect of SIRT7 on osteogenesis. SIRT7 knockdown significantly enhanced osteoblast-specific gen...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chen, Erman E M, Zhang, Wei, Ye, Chenyi C Y, Gao, Xiang, Jiang, Liangjun L J, Zhao, Tengfei T F, Pan, Zhijun Z J, Xue, Deting D T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636975/
https://ncbi.nlm.nih.gov/pubmed/28880264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.429
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