Upregulation of Parkin Accelerates Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Bone Regeneration by Enhancing Autophagy and β-Catenin Signaling

Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a higher risk of osteoporotic fracture. To inve...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Zhang, Wei, Hou, Weiduo, Chen, Mo, Chen, Erman, Xue, Deting, Ye, Chenyi, Li, Weixu, Pan, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523089/
https://ncbi.nlm.nih.gov/pubmed/33043010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.576104
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