Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches

Pristinamycin, produced by Streptomyces pristinaespiralis, which is a streptogramin-like antibiotic consisting of two chemically unrelated components: pristinamycin I (PI) and pristinamycin II (PII), shows potent activity against many antibiotic-resistant pathogens. However, so far pristinamycin pro...

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Pubblicato in:Synth Syst Biotechnol
Autori principali: Meng, Jiali, Feng, Rongrong, Zheng, Guosong, Ge, Mei, Mast, Yvonne, Wohlleben, Wolfgang, Gao, Jufang, Jiang, Weihong, Lu, Yinhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: KeAi Publishing 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636943/
https://ncbi.nlm.nih.gov/pubmed/29062970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2017.06.001
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