Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age

The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activati...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: de Jong, Britt G, IJspeert, Hanna, Marques, Lemelinda, van der Burg, Mirjam, van Dongen, Jacques JM, Loos, Bruno G, van Zelm, Menno C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636940/
https://ncbi.nlm.nih.gov/pubmed/28546550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2017.43
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