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MicroRNAs recruit eIF4E2 to repress translation of target mRNAs

MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress the translation of target mRNAs. While the 5′ 7-methylguanosine cap of target mRNAs has been well known to be important for miRNA repression, the underlying mechanism is not clear. Here we show that TNRC6A interacts with...

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Publicat a:Protein Cell
Autors principals: Chen, Shaohong, Gao, Guangxia
Format: Artigo
Idioma:Inglês
Publicat: Higher Education Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636748/
https://ncbi.nlm.nih.gov/pubmed/28755203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-017-0444-0
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