The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

Small isoprenoid diphosphates, such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), are ligands of the internal domain of BTN3A1. Ligand binding in target cells promotes activation of Vγ9Vδ2 T cells. We demonstrate by small-angle X-ray scattering (SAXS) that HMBPP binding to the internal d...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Nguyen, Khiem, Li, Jin, Puthenveetil, Robbins, Lin, Xiaochen, Poe, Michael M., Hsiao, Chia-Hung Christine, Vinogradova, Olga, Wiemer, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636706/
https://ncbi.nlm.nih.gov/pubmed/28705810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601370RR
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