Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We her...

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Udgivet i:PLoS One
Main Authors: Leitman, Ellen M., Palmer, Christine D., Buus, Søren, Chen, Fabian, Riddell, Lynn, Sims, Stuart, Klenerman, Paul, Sáez-Cirión, Asier, Walker, Bruce D., Hess, Paul R., Altfeld, Marcus, Matthews, Philippa C., Goulder, Philip J. R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636067/
https://ncbi.nlm.nih.gov/pubmed/29020090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184496
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