Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome

The replisome, the multiprotein system responsible for genome duplication, is a highly dynamic complex displaying a large number of different enzyme activities. Recently, the Saccharomyces cerevisiae minimal replication reaction has been successfully reconstituted in vitro. This provided an opportun...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lewis, Jacob S., Spenkelink, Lisanne M., Schauer, Grant D., Hill, Flynn R., Georgescu, Roxanna E., O’Donnell, Michael E., van Oijen, Antoine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635917/
https://ncbi.nlm.nih.gov/pubmed/28923950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711291114
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