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Reconstructing cancer drug response networks using multitask learning

BACKGROUND: Translating in vitro results to clinical tests is a major challenge in systems biology. Here we present a new Multi-Task learning framework which integrates thousands of cell line expression experiments to reconstruct drug specific response networks in cancer. RESULTS: The reconstructed...

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Publicat a:BMC Syst Biol
Autors principals: Ruffalo, Matthew, Stojanov, Petar, Pillutla, Venkata Krishna, Varma, Rohan, Bar-Joseph, Ziv
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635550/
https://ncbi.nlm.nih.gov/pubmed/29017547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0471-8
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