Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

ABT-737 is a pharmacological inhibitor of the anti-apoptotic activity of B-cell lymphoma-extra large (Bcl-xL) protein; it promotes apoptosis of cancer cells by occupying the BH3-binding pocket. We have shown previously that ABT-737 lowers cell metabolic efficiency by inhibiting ATP synthase activity...

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Опубликовано в: :Cell Death Differ
Главные авторы: Park, Han-A, Licznerski, Pawel, Mnatsakanyan, Nelli, Niu, Yulong, Sacchetti, Silvio, Wu, Jing, Polster, Brian M, Alavian, Kambiz N, Jonas, Elizabeth A
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635221/
https://ncbi.nlm.nih.gov/pubmed/28777375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.123
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