DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes

Adipose tissue inflammation is a central pathological element that regulates obesity-mediated insulin resistance and type II diabetes. Evidence demonstrates that extracellular signal-regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links tumor necrosis factor α (TNFα) to pro-inflammatory...

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Publicado no:Sci Rep
Main Authors: Habibian, Justine S., Jefic, Mitra, Bagchi, Rushita A., Lane, Robert H., McKnight, Robert A., McKinsey, Timothy A., Morrison, Ron F., Ferguson, Bradley S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635013/
https://ncbi.nlm.nih.gov/pubmed/29018280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12861-y
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