Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a key role in maintaining immune homeostasis. IL-10-mediated responses are triggered upon binding to a heterodimeric receptor complex consisting of IL-10 receptor (IL-10R)1 and IL-10R2. Engagement of the IL-10R complex activates the...

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Pubblicato in:PLoS One
Autori principali: Wilbers, Ruud H. P., van Raaij, Debbie R., Westerhof, Lotte B., Bakker, Jaap, Smant, Geert, Schots, Arjen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634637/
https://ncbi.nlm.nih.gov/pubmed/29016674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186317
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