A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice

Males and females use distinct brain circuits to cope with similar challenges. Using RNA sequencing of ribosome-bound mRNA from hippocampal CA3 neurons, we found remarkable sex differences and discovered that female mice displayed greater gene expression activation after acute stress than males. Str...

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Publicat a:Nat Commun
Autors principals: Marrocco, Jordan, Petty, Gordon H., Ríos, Mariel B., Gray, Jason D., Kogan, Joshua F., Waters, Elizabeth M., Schmidt, Eric F., Lee, Francis S., McEwen, Bruce S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634406/
https://ncbi.nlm.nih.gov/pubmed/28993643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01014-4
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