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Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis

The first crystal structures of the class D β-lactamases OXA-181 and OXA-245 were determined to 2.05 and 2.20 Å resolution, respectively; in addition, the structure of a new crystal form of OXA-163 was resolved to 2.07 Å resolution. All of these enzymes are OXA-48-like and have been isolated from di...

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Dettagli Bibliografici
Pubblicato in:Acta Crystallogr F Struct Biol Commun
Autori principali: Lund, Bjarte Aarmo, Thomassen, Ane Molden, Carlsen, Trine Josefine Olsen, Leiros, Hanna-Kirsti S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633926/
https://ncbi.nlm.nih.gov/pubmed/28994407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X17013838
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