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Function-Oriented Studies Targeting Pectenotoxin 2: Synthesis of the GH-Ring System and a Structurally Simplified Macrolactone
[Image: see text] A chemical foundation for function-oriented studies of pectenotoxin 2 (PTX2) is described. A synthesis of the bicyclic GH-system, and the design and synthesis of a PTX2-analogue, is presented. While maintaining critical features for actin binding, and lacking the Achilles’ heel for...
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| Gepubliceerd in: | Org Lett |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American
Chemical Society
2017
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5633828/ https://ncbi.nlm.nih.gov/pubmed/28901150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b02435 |
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