Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy

MicroRNAs (miRs) are frequently overexpressed in human cancers. In particular, miR-210 is induced in hypoxic cells and acts to orchestrate the adaptation of tumor cells to hypoxia. Silencing oncogenic miRs such as miR-210 may therefore offer a promising approach to anticancer therapy. We have develo...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Gupta, Anisha, Quijano, Elias, Liu, Yanfeng, Bahal, Raman, Scanlon, Susan E., Song, Eric, Hsieh, Wei-Che, Braddock, Demetrios E., Ly, Danith H., Saltzman, W. Mark, Glazer, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633812/
https://ncbi.nlm.nih.gov/pubmed/29246289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.09.001
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