Combination therapy using molecular‐targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma

Tumor growth and metastasis are determined not by cancer cells alone but also by a variety of stromal cells, various populations of which overexpress platelet‐derived growth factor receptors (PDGF‐Rs). In addition, activation of PI3K‐AKT‐mammalian target of rapamycin (mTOR) signaling is frequently o...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Med
Hauptverfasser: Kitano, Hiroyuki, Kitadai, Yasuhiko, Teishima, Jun, Yuge, Ryo, Shinmei, Shunsuke, Goto, Keisuke, Inoue, Shogo, Hayashi, Tetsutaro, Sentani, Kazuhiro, Yasui, Wataru, Matsubara, Akio
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633586/
https://ncbi.nlm.nih.gov/pubmed/28834289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1124
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