Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

Neurons affected in Parkinson’s disease (PD) experience mitochondrial dysfunction and bioenergetic deficits that occur early and promote the disease-related α-synucleinopathy. Emerging findings suggest that the autophagy-lysosome pathway, which removes damaged mitochondria (mitophagy), is also compr...

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Bibliographic Details
Published in:Front Neurol
Main Authors: Gao, Fei, Yang, Jia, Wang, Dongdong, Li, Chao, Fu, Yi, Wang, Huaishan, He, Wei, Zhang, Jianmin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632845/
https://ncbi.nlm.nih.gov/pubmed/29046661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2017.00527
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