Sustained Lesion and Shedding Rate Reductions in Genital Herpes Patients 24 Months after Immunization with GEN-003, a Genital Herpes Immunotherapy

BACKGROUND: Herpes simplex viruses (HSVs) are the main cause of genital ulcers worldwide. GEN-003 is an investigational genital herpes immunotherapy composed of HSV-2 antigens gD2DTMR and ICP4.2, and the saponin-based adjuvant Matrix-M2(TM) (MM2). In a Phase 2 dose-ranging study (GEN-003-002), 3 dos...

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Publicado no:Open Forum Infect Dis
Main Authors: Heineman, Thomas, Mcneil, Lisa K, Oliphant, Thomas, Natenshon, Andrew, Van Wagoner, Nicholas, Flechtner, Jessica B, Hetherington, Seth
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632159/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.720
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