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Traditional PK-PD Indices for Efficacy – Can We Do Better?

BACKGROUND: The relationship between antimicrobial activity and exposure relative to MIC is typically evaluated using one of three PK-PD indices, AUC:MIC ratio, Cmax:MIC ratio, and %T>MIC. However, under certain circumstances, none of these PK-PD indices may be the most optimal. These include whe...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Lakota, Elizabeth A, Bader, Justin C, Bhavnani, Sujata M, Andes, David R, Ambrose, Paul G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631980/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.685
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