Immune Senescence Factors Associated with the Immunogenicity of a Live Attenuated Zoster Vaccine (ZV) in Older Adults

BACKGROUND: ZV confers protection against herpes zoster by increasing the cell-mediated immunity (CMI) to varicella-zoster virus (VZV). ZV immunogenicity and protection decrease with increasing age. We investigated effects of age and immune senescence on ZV immunogenicity. METHODS: 399 adults ≥50 ye...

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Bibliografiske detaljer
Udgivet i:Open Forum Infect Dis
Main Authors: Weinberg, Adriana, Schamder, Kenneth, Johnson, Michael, Popmihajlov, Zoran, Tovar-Salazar, Adriana, Caldas, Yupanqui, Pang, Lei, Cho, Alice, Levin, Myron
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631485/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1036
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