Bivalent Norovirus VLP Vaccine Candidate in Older Adults: Impact of MPL and a Second Dose in a Randomized, Controlled, Double-Blind Clinical Trial

BACKGROUND: Acute norovirus (NoV) gastroenteritis may cause significant morbidity in healthy adults and can prove fatal in older subjects. We investigated the safety and immunogenicity in older adults of one or two doses of an intramuscular bivalent virus-like particle (VLP) vaccine candidate (genot...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Sherwood, Jim, Cramer, Jakob, Cam, Nancy Bouveret Le, Lin, Stella, Baehner, Frank, Mendelman, Paul, Borkowski, Astrid
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630829/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1047
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