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The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity dur...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630588/ https://ncbi.nlm.nih.gov/pubmed/28986560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00935-4 |
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