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Activation-Induced Conformational Changes of Dopamine D3 Receptor Promote the Formation of the Internal Water Channel
The atomic-level dopamine activation mechanism for transmitting extracellular ligand binding events through transmembrane helices to the cytoplasmic G protein remains unclear. In the present study, the complete dopamine D3 receptor (D3R), with a homology-modeled N-terminus, was constructed to dock d...
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| Published in: | Sci Rep |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630584/ https://ncbi.nlm.nih.gov/pubmed/28986565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13155-z |
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