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Targeted Proteomic Analyses of Histone H4 Acetylation Changes Associated with Homologous-Recombination-Deficient High-Grade Serous Ovarian Carcinomas
Approximately 20% of high-grade serous ovarian cancers are homologous-recombination (HR)-deficient due to genetic and epigenetic mutations of HR pathway genes including the tumor suppressor genes BRCA1 and 2. HR deficiency (HRD) compromises cells’ ability to efficiently repair DNA damage, but it als...
Shranjeno v:
| izdano v: | J Proteome Res |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630524/ https://ncbi.nlm.nih.gov/pubmed/28866885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.7b00405 |
| Oznake: |
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