Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood. We used patient-derived GBM cultures to identify GSC subtypes with differential activation of Notch...

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Publicat a:Oncotarget
Autors principals: Bayin, N. Sumru, Frenster, Joshua D., Sen, Rajeev, Si, Sheng, Modrek, Aram S., Galifianakis, Nataliya, Dolgalev, Igor, Ortenzi, Valerio, Illa-Bochaca, Irineu, Khahera, Anadjeet, Serrano, Jonathan, Chiriboga, Luis, Zagzag, David, Golfinos, John G., Doyle, Werner, Tsirigos, Aristotelis, Heguy, Adriana, Chesler, Mitch, Barcellos-Hoff, Mary Helen, Snuderl, Matija, Placantonakis, Dimitris G.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630302/
https://ncbi.nlm.nih.gov/pubmed/29029402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18117
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