Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood. We used patient-derived GBM cultures to identify GSC subtypes with differential activation of Notch...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bayin, N. Sumru, Frenster, Joshua D., Sen, Rajeev, Si, Sheng, Modrek, Aram S., Galifianakis, Nataliya, Dolgalev, Igor, Ortenzi, Valerio, Illa-Bochaca, Irineu, Khahera, Anadjeet, Serrano, Jonathan, Chiriboga, Luis, Zagzag, David, Golfinos, John G., Doyle, Werner, Tsirigos, Aristotelis, Heguy, Adriana, Chesler, Mitch, Barcellos-Hoff, Mary Helen, Snuderl, Matija, Placantonakis, Dimitris G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630302/
https://ncbi.nlm.nih.gov/pubmed/29029402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18117
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