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Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood. We used patient-derived GBM cultures to identify GSC subtypes with differential activation of Notch...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Bayin, N. Sumru, Frenster, Joshua D., Sen, Rajeev, Si, Sheng, Modrek, Aram S., Galifianakis, Nataliya, Dolgalev, Igor, Ortenzi, Valerio, Illa-Bochaca, Irineu, Khahera, Anadjeet, Serrano, Jonathan, Chiriboga, Luis, Zagzag, David, Golfinos, John G., Doyle, Werner, Tsirigos, Aristotelis, Heguy, Adriana, Chesler, Mitch, Barcellos-Hoff, Mary Helen, Snuderl, Matija, Placantonakis, Dimitris G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630302/
https://ncbi.nlm.nih.gov/pubmed/29029402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18117
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