Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis

Replication-transcription collisions shape genomes, influence evolution, and promote genetic diseases. Although unclear why, head-on transcription (lagging strand genes) is especially disruptive to replication and promotes genomic instability. Here, we find that head-on collisions promote R-loop for...

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Gepubliceerd in:Cell
Hoofdauteurs: Lang, Kevin S., Hall, Ashley N., Merrikh, Christopher N., Ragheb, Mark, Tabakh, Hannah, Pollock, Alex J., Woodward, Joshua J., Dreifus, Julia E., Merrikh, Houra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630229/
https://ncbi.nlm.nih.gov/pubmed/28802046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.044
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