A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

BACKGROUND: Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label stud...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Gore, Lia, Triche, Timothy J., Farrar, Jason E., Wai, Daniel, Legendre, Christophe, Gooden, Gerald C., Liang, Winnie S., Carpten, John, Lee, David, Alvaro, Frank, Macy, Margaret E., Arndt, Carola, Barnette, Philip, Cooper, Todd, Martin, Laura, Narendran, Aru, Pollard, Jessica, Meshinchi, Soheil, Boklan, Jessica, Arceci, Robert J., Salhia, Bodour
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629751/
https://ncbi.nlm.nih.gov/pubmed/29034009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0411-x
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