Unraveling Complexity in the Solid Form Screening of a Pharmaceutical Salt: Why so Many Forms? Why so Few?

[Image: see text] The solid form landscape of 5-HT2a antagonist 3-(4-(benzo[d]isoxazole-3-yl)piperazin-1-yl)-2,2-dimethylpropanoic acid hydrochloride (B5HCl) proved difficult to establish. Many crystalline materials were produced by solid form screening, but few forms readily grew high quality cryst...

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Библиографические подробности
Опубликовано в: :Cryst Growth Des
Главные авторы: Braun, Doris E., Lingireddy, Sreenivas R., Beidelschies, Mark D., Guo, Rui, Müller, Peter, Price, Sarah L., Reutzel-Edens, Susan M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2017
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629560/
https://ncbi.nlm.nih.gov/pubmed/29018305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.cgd.7b00842
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