Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is bound by the cochaperone Bag-1L. Mutations in t...

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Vydáno v:eLife
Hlavní autoři: Cato, Laura, Neeb, Antje, Sharp, Adam, Buzón, Victor, Ficarro, Scott B, Yang, Linxiao, Muhle-Goll, Claudia, Kuznik, Nane C, Riisnaes, Ruth, Nava Rodrigues, Daniel, Armant, Olivier, Gourain, Victor, Adelmant, Guillaume, Ntim, Emmanuel A, Westerling, Thomas, Dolling, David, Rescigno, Pasquale, Figueiredo, Ines, Fauser, Friedrich, Wu, Jennifer, Rottenberg, Jaice T, Shatkina, Liubov, Ester, Claudia, Luy, Burkhard, Puchta, Holger, Troppmair, Jakob, Jung, Nicole, Bräse, Stefan, Strähle, Uwe, Marto, Jarrod A, Nienhaus, Gerd Ulrich, Al-Lazikani, Bissan, Salvatella, Xavier, de Bono, Johann S, Cato, Andrew CB, Brown, Myles
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629025/
https://ncbi.nlm.nih.gov/pubmed/28826504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27159
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