Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is bound by the cochaperone Bag-1L. Mutations in t...

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Bibliographic Details
Published in:eLife
Main Authors: Cato, Laura, Neeb, Antje, Sharp, Adam, Buzón, Victor, Ficarro, Scott B, Yang, Linxiao, Muhle-Goll, Claudia, Kuznik, Nane C, Riisnaes, Ruth, Nava Rodrigues, Daniel, Armant, Olivier, Gourain, Victor, Adelmant, Guillaume, Ntim, Emmanuel A, Westerling, Thomas, Dolling, David, Rescigno, Pasquale, Figueiredo, Ines, Fauser, Friedrich, Wu, Jennifer, Rottenberg, Jaice T, Shatkina, Liubov, Ester, Claudia, Luy, Burkhard, Puchta, Holger, Troppmair, Jakob, Jung, Nicole, Bräse, Stefan, Strähle, Uwe, Marto, Jarrod A, Nienhaus, Gerd Ulrich, Al-Lazikani, Bissan, Salvatella, Xavier, de Bono, Johann S, Cato, Andrew CB, Brown, Myles
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629025/
https://ncbi.nlm.nih.gov/pubmed/28826504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27159
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