Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is bound by the cochaperone Bag-1L. Mutations in t...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Cato, Laura, Neeb, Antje, Sharp, Adam, Buzón, Victor, Ficarro, Scott B, Yang, Linxiao, Muhle-Goll, Claudia, Kuznik, Nane C, Riisnaes, Ruth, Nava Rodrigues, Daniel, Armant, Olivier, Gourain, Victor, Adelmant, Guillaume, Ntim, Emmanuel A, Westerling, Thomas, Dolling, David, Rescigno, Pasquale, Figueiredo, Ines, Fauser, Friedrich, Wu, Jennifer, Rottenberg, Jaice T, Shatkina, Liubov, Ester, Claudia, Luy, Burkhard, Puchta, Holger, Troppmair, Jakob, Jung, Nicole, Bräse, Stefan, Strähle, Uwe, Marto, Jarrod A, Nienhaus, Gerd Ulrich, Al-Lazikani, Bissan, Salvatella, Xavier, de Bono, Johann S, Cato, Andrew CB, Brown, Myles
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629025/
https://ncbi.nlm.nih.gov/pubmed/28826504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27159
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