Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is bound by the cochaperone Bag-1L. Mutations in t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Cato, Laura, Neeb, Antje, Sharp, Adam, Buzón, Victor, Ficarro, Scott B, Yang, Linxiao, Muhle-Goll, Claudia, Kuznik, Nane C, Riisnaes, Ruth, Nava Rodrigues, Daniel, Armant, Olivier, Gourain, Victor, Adelmant, Guillaume, Ntim, Emmanuel A, Westerling, Thomas, Dolling, David, Rescigno, Pasquale, Figueiredo, Ines, Fauser, Friedrich, Wu, Jennifer, Rottenberg, Jaice T, Shatkina, Liubov, Ester, Claudia, Luy, Burkhard, Puchta, Holger, Troppmair, Jakob, Jung, Nicole, Bräse, Stefan, Strähle, Uwe, Marto, Jarrod A, Nienhaus, Gerd Ulrich, Al-Lazikani, Bissan, Salvatella, Xavier, de Bono, Johann S, Cato, Andrew CB, Brown, Myles
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Cancer Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629025/
https://ncbi.nlm.nih.gov/pubmed/28826504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27159
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