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mAb MDR1-modified chitosan nanoparticles overcome acquired EGFR-TKI resistance through two potential therapeutic targets modulation of MDR1 and autophagy

BACKGROUND: Tyrosine kinase inhibitors (TKIs) that act against the epithelial growth factor receptor (EGFR) were once widely used in chemotherapy for many human cancers. However, acquired chemoresistance occurred in almost all patients, limiting the clinical application of EGFR-TKI. Thus far, no eff...

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書目詳細資料
發表在:J Nanobiotechnology
Main Authors: Zheng, Yan, Su, Chang, Zhao, Liang, Shi, Yijie
格式: Artigo
語言:Inglês
出版: BioMed Central 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628454/
https://ncbi.nlm.nih.gov/pubmed/28978341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-017-0302-5
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