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New fluphenazine analogue with antimutagenic and anti-multidrug resistance activity—degradation profile and stability-indicating method

Hydrochloride of 10-{2-hydroxy-3-[N,N-bis-(2-hydroxyethyl)amino]propyl}-2-trifluoromethylphenothiazine (Flu-A) is a analogue of neuroleptic fluphenazine. Flu-A exhibits anti-multidrug resistance, antimutagenic, proapoptopic, and cancer-chemopreventive activities in screening studies. To define ident...

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Detalhes bibliográficos
Publicado no:Med Chem Res
Main Authors: Sobczak, Agnieszka, Teżyk, Artur, Szyndlarewicz, Joanna, Ziarniak, Jan, Świątek, Piotr, Malinka, Wiesław
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628186/
https://ncbi.nlm.nih.gov/pubmed/29051697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-017-1944-4
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