New fluphenazine analogues as inhibitors of P-glycoprotein in human lymphocyte cultures

AIM OF THE STUDY: To evaluate the inhibitory effect of 17 new analogues of FPh on the Pgp transport function, by estimation of the rhodamine 123 (Rod-123) accumulation inside cultured lymphocytes. MATERIAL AND METHODS: Lymphocyte were cultured in the presence of a lectin (PHA; 2%, v/v), incubated wi...

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Detalhes bibliográficos
Main Authors: Jaszczyszyn, Agata, Gąsiorowski, Kazimierz, Świątek, Piotr, Malinka, Wiesław, Cieślik-Boczula, Katarzyna, Petrus, Joanna, Czarnik-Matusewicz, Bogusława
Formato: Artigo
Idioma:Inglês
Publicado em: Termedia Publishing House 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687430/
https://ncbi.nlm.nih.gov/pubmed/23788904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/wo.2012.30063
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