A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity

The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneous injection of site-specific (C-terminal) co...

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Bibliographic Details
Published in:Nat Biomed Eng
Main Authors: Qi, Yizhi, Simakova, Antonina, Ganson, Nancy J., Li, Xinghai, Luginbuhl, Kelli M., Özer, Imran, Liu, Wenge, Hershfield, Michael S., Matyjaszewski, Krzysztof, Chilkoti, Ashutosh
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627778/
https://ncbi.nlm.nih.gov/pubmed/28989813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-016-0002
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