Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart

Abstract Protein therapeutics, except for antibodies, have a short plasma half‐life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. In addition to induced PEG antibod...

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Xehetasun bibliografikoak
Egile Nagusiak: Imran Ozer, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, Joel H. Collier, Michael S. Hershfield, Angus M. Hucknall, Ashutosh Chilkoti
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wiley 2022-04-01
Saila:Advanced Science
Gaiak:
antigenicity
immunogenicity
pegloticase
pharmacokinetics
polyethylene glycol
polyethylene glycol antibody
Sarrera elektronikoa:https://doi.org/10.1002/advs.202103672
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