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Targeting the alternative sigma factor RpoN to combat virulence in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that infects immunocompromised and cystic fibrosis patients. Treatment is difficult due to antibiotic resistance, and new antimicrobials are needed to treat infections. The alternative sigma factor 54 (σ(54), RpoN), regulates many vir...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lloyd, Megan G., Lundgren, Benjamin R., Hall, Clayton W., Gagnon, Luke B.-P., Mah, Thien-Fah, Moffat, Jennifer F., Nomura, Christopher T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626770/
https://ncbi.nlm.nih.gov/pubmed/28974743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12667-y
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