High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses

To secure a polio-free world, the live attenuated oral poliovirus vaccine (OPV) will eventually need to be replaced with inactivated poliovirus vaccines (IPV). However, current IPV delivery is less suitable for campaign use than OPV, and more expensive. We are progressing a microarray patch delivery...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Muller, David A., Fernando, Germain J. P., Owens, Nick S., Agyei-Yeboah, Christiana, Wei, Jonathan C. J., Depelsenaire, Alexandra C. I., Forster, Angus, Fahey, Paul, Weldon, William C., Oberste, M. Steven, Young, Paul R., Kendall, Mark A. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626768/
https://ncbi.nlm.nih.gov/pubmed/28974777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13011-0
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