Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses

Chemical adjuvants are typically used to improve immune responses induced by immunisation with protein antigens. Here we demonstrate an approach to enhance immune responses that does not require chemical adjuvants. We applied microprojection arrays to the skin, producing a range of controlled mechan...

Full description

Saved in:
Bibliographic Details
Published in:NPJ Vaccines
Main Authors: Ng, Hwee-Ing, Tuong, Zewen K., Fernando, Germain J. P., Depelsenaire, Alexandra C. I., Meliga, Stefano C., Frazer, Ian H., Kendall, Mark A. F.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789026/
https://ncbi.nlm.nih.gov/pubmed/31632742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-019-0134-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items