Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy

Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both...

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izdano v:Sci Rep
Main Authors: Salker, Madhuri S., Singh, Yogesh, Zeng, Ni, Chen, Hong, Zhang, Shaqiu, Umbach, Anja T, Fakhri, Hajar, Kohlhofer, Ursula, Quintanilla-Martinez, Leticia, Durairaj, Ruban R. Peter, Barros, Flavio S. V., Vrljicak, Pavle, Ott, Sascha, Brucker, Sara Y, Wallwiener, Diethelm, Vrhovac Madunić, Ivana, Breljak, Davorka, Sabolić, Ivan, Koepsell, Hermann, Brosens, Jan J., Lang, Florian
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626729/
https://ncbi.nlm.nih.gov/pubmed/28974690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11674-3
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