A Rab5 GTPase module is important for autophagosome closure

In the conserved autophagy pathway, the double-membrane autophagosome (AP) engulfs cellular components to be delivered for degradation in the lysosome. While only sealed AP can productively fuse with the lysosome, the molecular mechanism of AP closure is currently unknown. Rab GTPases, which regulat...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Zhou, Fan, Zou, Shenshen, Chen, Yong, Lipatova, Zhanna, Sun, Dan, Zhu, Xiaolong, Li, Rui, Wu, Zulin, You, Weiming, Cong, Xiaoxia, Zhou, Yiting, Xie, Zhiping, Gyurkovska, Valeriya, Liu, Yutao, Li, Qunli, Li, Wenjing, Cheng, Jie, Liang, Yongheng, Segev, Nava
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626503/
https://ncbi.nlm.nih.gov/pubmed/28934205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007020
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