PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Yan, Bing-Ru, Zhou, Lu, Hu, Ming-Ming, Li, Mi, Lin, Heng, Yang, Yan, Wang, Yan-Yi, Shu, Hong-Bing
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626498/
https://ncbi.nlm.nih.gov/pubmed/28934360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006648
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