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Engineering a light-activated caspase-3 for precise ablation of neurons in vivo

The circuitry of the brain is characterized by cell heterogeneity, sprawling cellular anatomy, and astonishingly complex patterns of connectivity. Determining how complex neural circuits control behavior is a major challenge that is often approached using surgical, chemical, or transgenic approaches...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Smart, Ashley D., Pache, Roland A., Thomsen, Nathan D., Kortemme, Tanja, Davis, Graeme W., Wells, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625904/
https://ncbi.nlm.nih.gov/pubmed/28893998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705064114
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