The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma

BACKGROUND: Matrix metalloproteinase-8 (MMP-8) has oncosuppressive properties in various cancers. We attempted to assess MMP-8 function in oral tongue squamous cell carcinoma (OTSCC). METHODS: MMP-8 overexpressing OTSCC cells were used to study the effect of MMP-8 on proliferation, apoptosis, migrat...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Åström, Pirjo, Juurikka, Krista, Hadler-Olsen, Elin S, Svineng, Gunbjørg, Cervigne, Nilva K, Coletta, Ricardo D, Risteli, Juha, Kauppila, Joonas H, Skarp, Sini, Kuttner, Samuel, Oteiza, Ana, Sutinen, Meeri, Salo, Tuula
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625665/
https://ncbi.nlm.nih.gov/pubmed/28772283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.249
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