Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion

BACKGROUND: Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously observed elevated expression of uPAR at the tumour-stroma interface in a mouse...

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Pubblicato in:BMC Cancer
Autori principali: Magnussen, Synnove Norvoll, Hadler-Olsen, Elin, Costea, Daniela Elena, Berg, Eli, Jacobsen, Cristiane Cavalcanti, Mortensen, Bente, Salo, Tuula, Martinez-Zubiaurre, Inigo, Winberg, Jan-Olof, Uhlin-Hansen, Lars, Svineng, Gunbjorg
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438506/
https://ncbi.nlm.nih.gov/pubmed/28526008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3349-7
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