Immunodominance of Adenovirus-Derived CD8(+) T Cell Epitopes Interferes with the Induction of Transgene-Specific Immunity in Adenovirus-Based Immunization

Adenovirus (Ad)-based immunization is a popular approach in vaccine development, and Ad-based vectors are renowned for their potential to induce strong CD8(+) T cell responses to the encoded transgene. Surprisingly, we previously found in the mouse Friend retrovirus (FV) model that Ad-based immuniza...

Full description

Saved in:
Bibliographic Details
Published in:J Virol
Main Authors: Schöne, Dominik, Hrycak, Camilla Patrizia, Windmann, Sonja, Lapuente, Dennis, Dittmer, Ulf, Tenbusch, Matthias, Bayer, Wibke
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625516/
https://ncbi.nlm.nih.gov/pubmed/28768877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01184-17
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items