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Interference of retroviral envelope with vaccine-induced CD8(+) T cell responses is relieved by co-administration of cytokine-encoding vectors

BACKGROUND: Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, where envelope interferes with the induction of CD8(+) T cell responses towards...

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Dettagli Bibliografici
Pubblicato in:Retrovirology
Autori principali: Bongard, Nadine, Lapuente, Dennis, Windmann, Sonja, Dittmer, Ulf, Tenbusch, Matthias, Bayer, Wibke
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408827/
https://ncbi.nlm.nih.gov/pubmed/28449719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-017-0352-7
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