Semisynthetic prion protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrils

The prion protein (PrP) is an N-glycosylated protein attached to the outer leaflet of eukaryotic cell membranes via a glycosylphosphatidylinositol (GPI) anchor. Different prion strains have distinct glycosylation patterns and the extent of glycosylation of potentially pathogenic misfolded prion prot...

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Udgivet i:Chem Sci
Main Authors: Araman, Can, Thompson, Robert E., Wang, Siyao, Hackl, Stefanie, Payne, Richard J., Becker, Christian F. W.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2017
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625290/
https://ncbi.nlm.nih.gov/pubmed/28989689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02719b
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