Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation

Despite the consistent rise of non-alcoholic steatohepatitis (NASH) worldwide, the mechanisms that govern the inflammatory aspect of this disease remain unknown. Previous research showed an association between hepatic inflammation and lysosomal lipid accumulation in blood-derived hepatic macrophages...

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Published in:Sci Rep
Main Authors: Houben, Tom, Oligschlaeger, Yvonne, Bitorina, Albert V., Hendrikx, Tim, Walenbergh, Sofie M. A., Lenders, Marie-Hélène, Gijbels, Marion J. J., Verheyen, Fons, Lütjohann, Dieter, Hofker, Marten H., Binder, Christoph J., Shiri-Sverdlov, Ronit
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624963/
https://ncbi.nlm.nih.gov/pubmed/28970532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13058-z
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